Are simulators similar to game engines?

Imagine I want to make chemistry-biology simulator. Is the structure similar to a game engine ? Physics, render, math, audio and i/o cores ?

From what I know, simulators are very similar to game engines. In fact I’d call them game engines with a focus on being more accurate in simulating something, be it physics or some task like driving. They usually don’t focus as much on graphics because they don’t have to, so the graphics can be much more basic. Unreal Engine 4 is trying to break into the simulation industry with their graphics capabilities.
Though, there are some really heavy duty simulators that take hours or months to run and they don’t have a realtime component to them.

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