I made an organism with Macrolide Toxins in order to try and get the Toxic vacuole through endosymbiosis. This was using Custom Difficulty with 0.2 Mutation Cost, 0.2 Energy Cost, 0.7 AI Mutation Rate, 3 (Max) Resource Spawn rate, 0.95 Glucose retention rate, no organelle unlocks, no fog, Non-Lawk Enabled, and Experimental Settings Enabled. The world had all resources very high, the world size was Small, had Medium sized oceans, High Planet Temperature, Unstable Climate, and Active geology settings. Also, played on OpenGL Mode. After engulfing an organism with toxins, I took damage. When the engulfed matter reached zero, I still kept on taking damage until I died. I thought this might be something related to upgrading a save from the previous version (1.0.1.1), so I made a fresh game in 1.1.0.0 using the same game settings, but a new random seed with the same world generation settings. The Zero Engulfed Matter Toxin Damage bug happened several times with engulfing organisms with toxins in the new fresh game. I loaded an earlier auto-save from the fresh game, did the same thing, and I was still taking damage from zero engulfed matter from an toxin containing organism. I tried reloading the save, going back to the main menu and reloading, and restarting the game, nothing worked. This bug makes it impossible to eat toxic organisms, even when using the Double Membrane.
Edit: It appears to be a bug with Experimental Settings, as I started a fresh playthrough without Experimental Settings enabled and was able to properly digest toxic organisms.[1]
Only to find out that the endosymbiosis target devolved the toxin. β©οΈ