I suppose the chimera in question isn’t a xenobot, it can reproduce and it has a like an embrionic development, its just that the development is artificially designed.
You can mutate a hox gene of a mosquito and make its legs grow on its head*. I guess you can make a totally alien organ develop too.
I think a chimera could survive a generation, but it wouldn’t survive evolution. Because there are incompatabilites, codon or more fundamental incompatabilities in the case of alien chimeras, and molecular (for example, can you get a blood donation from a horseshoe crab?) and biomechatronic incompatabilities in the case of a chimera between two species in the same planet.
They would be outcompeted by a species that doesn’t have translators and redundant systems.