Senescence can be induced in worms by manipulating Transciption Factor TFEB.
P.S.: U.S. budget cuts mean even Nature is now charging to view full articles. 
2 Likes
I kind of find it weird some people who otherwise make really good videos seem to argue that death (in entirety) can be âeliminatedâ to allow us to live âforeverâ even though thereâs no way to support metabolism on an universal timescales.
1 Like
This is assuming people donât go crazy due to living for such a long time.
2 Likes
Thatâd be a problem with immortality Iâd image many donât consider at firstâŚ
1 Like
i assume that after at least 10000 years they will had solved all psychological problems they could have
3 Likes
What to do then for all that time?
1 Like
I find the pro-death crowd deeply confusing. A lot of the people who argue for immortality are weird, yes. EXTREMELY yes. But, use your brain. Think about it. If you are told by an all powerful entity you will life to 60, no matter what you do, unless you push this button, which will let you live to 80, do you press it? I would. If you are told by an all powerful entity you will live to 80, but you can press this button and live to 100, do you press it? Iâd ask a probing question or two about dementia and osteoporosis, but in general, yes. This pattern extends. How far does it extend? I have no clue. I want to live in a world where we are testing how far that pattern extends. Iâm not saying we curse everyone to live forever against their will. I really hope no one is saying that. I think people should be able to opt out of death. Think of it like any other disease. No one says âahh, but naturally, you would have died of cancer, so, letâs see you live a decade past you time, and Iâll bet you come back begging to be killedâ, that sounds insane. Obvious living 100,000 years also sounds insane. There is, however, 100,000 years of middle ground.
as for what to do with all that time- I can speak like one and two thirds languages, at best. I want to read classic russian literature and soviet declassified documents in russian. I want to make a video game. I want to contribute to thrive. I want to write a book. I want to learn langauges. lots of them. I want to write an operating system. I want to learn pdp 11 assembly. I want to go to trade school and learn to repair cars. I want to grow a garden. I want a lot of things that have nothing to do with nerd stuff/are quite personal. If you canât think of something to do for 300 years, i think thatâs a you problem. If you donât think that existing in the world is enjoyable, I think we should fix the world. If you think nothing interesting will be invented in the time it takes you to do all the things you want to do, you underestimate the world, and the 8+ billion others making amazing things. Iâd like to go to Venus. Iâd like to build a submarine. If people go crazy, then so be it. They had longer, happier lives than any of us would have, even if just for a few hundred years. i think a 200 year life expectancy wonât cause madness, will raise happiness, and would be worth it.
I also think that after a few hundred years of that, we wouldnât have stopped curing diseases, and weâd actually say ârisk of insanity is super low, everyone enjoys their long life, people tend not to be happy to die, why donât we look into living 500 years!â so uh
6 Likes
Pretty sure human brains still have a max capacity as to how much they can remember. After a few thousand years or so it wouldnât be surprising if you began forgetting whole years if not decades of your life.
1 Like
That remind me that story:
For those who want a summary of the short story - it talks about a character who has lived for several thousand years with the ability to control blood (hematmnesia). He invites an artist to draw him because he has lived so long that he has dementia because he is unable to remember how long he has lived And wants to remember the moment of the current period.
2 Likes
The point is that âvery long lifespanâ and âimmortalityâ are completely different, the fact that people which donât see the issues with immortality donât understand this is further evidence that people would suffer under the realities of an infinite lifespan.
3 Likes
Speaking of long lives, how long would you the people of Thrive Community Forums want to live in an ideal scenario where various techs needed to extend lifespan are invented?
1 Like
However long Iâd live due to sheer willpower.
2 Likes
So until you go insane, right?
1 Like
Here is the thing. If someone lives a long time, would they be any more motivated to do things than what that person is doing now? People could actually procrastinate more, thinking, âSince I will live for such along time, why not wait to do things?â. Or something along similar lines. Having a finite deadline in terms of life is absolutely terrifying, but it can also serve as reminder and motivator to get things done.
2 Likes
I donât think a 100% immortality is possible so they would still need to remember their lifetime is finite.
1 Like
i usually donât think âhey i might die in some decades so better i finish this drawingâ
thats quite complicated? Like, i would enjoy living eternally because there is a nearly infinite number of things i can do, but i think that dying, as an way to rest from existence, would be nice if it wasnât permanent. i would gladly follow the âcity and the starsâ system, where people live in cycles of 1000 years, choose the memories they want to keep, and get put in rest for a undetermined time.
if you didnât figured out by then how to expand the brain limit using tech, that would be an very big skill issue
exactly, and based.
6 Likes
Limits would still remain, they would just manifest after a longer timeâŚ
1 Like
I agree. Someone who tires of an infinite life (or at least a very long one) can just commit suicide.[1] Isnât dying on my own terms better than contracting a disease and risk dying a painful death or cognitive decline?[2]
No? Of course, I canât possibly fathom the concept of living 500, 1 000, 1 000 000, â years,[3] but I donât think people base their motivation to do stuff on mortality (at least, most of the time) and, as other people have already said: there are a lot of things to do in the world (or worlds).[4]
Iâm interpreting that weâre talking about not dying of natural causes, not immortal as in ânot capable of dying in any wayâ. âŠď¸
If I had a penny for each time Iâve breached the topic of suicide on this forum, Iâd have two pennies; it isnât much, but itâs concerning either way. âŠď¸
I think I canât fathom someone living more than 90 years. âŠď¸
Just watch out for the inevitable death of the universe. That doesnât seem comfortable at all. âŠď¸
2 Likes
the human brain just grows more cells and packs them denser when it needs more storage space
and you literally donât even need to run out of storage space to forget years or decades of your life
all you need to do that is depression or trauma
or brain damage
personally, i think living to 100,000 is rookie numbers
the least i will settle for unless something really bad happens first, is outliving the sun.
and like
there are thousands of things you could do with 1 billion years, much less 100 billion to a few trillion years
for example
make an actual seed world, and document evolution as it happens
build a planet
research how to stop every possible end to the universe
figure out how to create artificial universes that exist in a separate set of dimensions from us, and can only interact with our universe through portals
figure out how to make a computer that can simulate a stronger computer
research how to make a self-running simulation(as in, a simulation that can run a computer with more computation power than the original host computer, and can also use the processor of the computer inside the simulation to run, at the cost of speed)
looks at electrotrophic bacteria, deinococcus radiodurans, and strong electrets(which will be invented within 10-500 years)
looks at high-entropy alloys and plasma barriers
looks at gene editing technology and protein folding algorithms
looks at the genes that cause the neurons that produce dopamine to be more likely to die
looks at the three scribes method of error correction
looks at how tardigrades and deinococcus radiodurans sheild their DNA from damage
looks at the genes that cause high neuroplasticity to be more likely to retain into adulthood
looks at the fact that cells only need a way to recycle enough ATP, nutrient input, and somewhere to put waste products to survive, and not anything that they canât get from inside a closed system
looks at the genes that cause your metabolism to slow down as you age
looks at telomerase and DNA de-methylation
looks at photonic computing and active danger avoidance systems
looks at how the heat death of the universe is entirely preventable
looks at how you only need to not be where everything else collides to survive the big crunch
theyâre literally just misfolded proteins
all you need to do is unfold them or shred them into amino acids and ammonia
and what are the problems you see with having an infinite lifespan?
loneliness?
just make other people immortal with you
you have literally all the time in the universe to find them.[quote=âaah31415, post:8238, topic:5842, full:trueâ]
Pretty sure human brains still have a max capacity as to how much they can remember. After a few thousand years or so it wouldnât be surprising if you began forgetting whole years if not decades of your life.
[/quote]
boredom?
make some seed worlds
learn to code
figure out how to simulate a universe that runs faster than our own
invent new types of exotic life
find new games to play, there are literally infinite possible computer games
disease?
just cure it. as long as itâs not deadly, you have all the time in the universe
if it is deadly, you have until it kills you
and if you canât cure it, use it as an excuse to upgrade yourself
for example, if itâs brain cancer, grow your brain with neurons that have a completely custom built genome, and compute or at least communicate with light, and then wean your consciousness off of your human brain, by slowly decreasing the energy your human brain bits receive.
if you notice something going wrong, you can just increase its energy budget again, and find out what went wrong, so you can fix it
and thatâs the hardest one you can do, aside from killing off an autoimmune disease, which takes killing off your immune system
why would going insane be a reason to end your life?
being sane is boooring!!
having some of your screws loose, some missing, and a few hanging on by the edges of their threads is fun!
and makes you fun to be around!
i already do that
and due to how belgiumed up my sense of scale gets when it comes to time, i doubt that how much i do it will change at all if i become functionally immortal
like, a temporary afterlife? or a way to just temporarily go back into the void you lived in before you were born, but for a longer time period than sleep lets you?
there really isnât one except your skull
the thing about the human brain having finite capacity was proven false a while ago
mainly due to 2 things
how memories are formed, and how you do actually produce neurons after your brain finishes expanding
long-term memories are formed by creating or reinforcing axons, using medium-term memory
medium term memory is formed by processing the information in your working memory, which is an effortless process that only requires you set aside some time where you arenât thinking or processing too much stimuli
short-term memory is formed by taking in stimuli or thinking
and neurogenesis was confirmed to continue up until your neuron progenitor stem cells run out of telomeres, which is when dementia starts kicking in if youâre predisposed to it
and if it didnât continue past childhood, adults would be nearly incapable of healing or recovering from even moderate brain damage without stem cell therapy.
and, if you take telomere shortening out of the equation, the brain grows denser as you age, and gets more and more powerful, until it simply canât get denser
which means you just need to take it out of your skull, and put it in a larger container
and if that isnât enough, upgrade the cells of your brain
make each cell be a ganglion
give each cell a brain made out of prokaryotes that have the sole purpose of acting as neurons do, but that communicate using insulated nanowires, rather than action potentials
make your neurons be 1-2 um long, and make their host cells communicate with bundles of optical fibers
and that lets you have electrical gangliocytes be able to directly communicate with optical neurons
or, even better, photonic gangliocytes, since gold nanospheres and SiO2 nanospheres can get down to 10 nm, and thereâs no reason you canât do multilayered computing
and itâd be pretty belgiuming easy to make an enzyme that uses a specialized type of non-encoding DNA to store the instructions to make different structures
2 Likes
Extraordinary claims require extraordinary evidence, and this is one hell of an extraordinary claim.
Please do tell what perpetual motion machine shenanigans you have in mind, and how you plan to not get banned from the patent office.
1 Like