Challenge runs

[aah31415 (The maker of SitF, Radiostrocity, The Lifenote and TGBing; The Second Ascended...; And just maybe a security warning come alive...?)]

What would be the chance of clicking the button each second after it becomes active?

[AnthropocenianAge (AnthropocenianAge Arthropleura wants to give you a hug!)]

Randomly determine it (probably 50%).

[aah31415 (The maker of SitF, Radiostrocity, The Lifenote and TGBing; The Second Ascended...; And just maybe a security warning come alive...?)]

Seems kind of high of a chance…

[AnthropocenianAge (AnthropocenianAge Arthropleura wants to give you a hug!)]

Tunnel Vision - Complete the game using the minimum zoom level; you are as zoomed in as possible.

Inspired from these comments:

@Rathalos

It’s a shame that the default max zoom is so wide out that you can barely see the structure of cells. Because since zooming all the way out as far as possible is optimal gameplay, that feels like people are missing a lot of the graphical experience.

[aah31415 (The maker of SitF, Radiostrocity, The Lifenote and TGBing; The Second Ascended...; And just maybe a security warning come alive...?)]

Memorization: Finish Thrive Blindfolded

[AnthropocenianAge (AnthropocenianAge Arthropleura wants to give you a hug!)]

Admin! He is going sideways! - Finish Thrive by moving sideways and hopping sideways (where applicable).

[aah31415 (The maker of SitF, Radiostrocity, The Lifenote and TGBing; The Second Ascended...; And just maybe a security warning come alive...?)]

By hopping sideways do you mean in macroscopic+ stages?

[AnthropocenianAge (AnthropocenianAge Arthropleura wants to give you a hug!)]

Engulf-ception - You can only engulf cells that have themselves engulfed chunks or other cells.

[aah31415 (The maker of SitF, Radiostrocity, The Lifenote and TGBing; The Second Ascended...; And just maybe a security warning come alive...?)]

Yuck! - Manually eject engulfed items (a counterpart to the “Yum!” achievement)

[Ill_try_at_least (All warfare is based on deceptions)]

Wouldn’t this be closer to an achievment?

[aah31415 (The maker of SitF, Radiostrocity, The Lifenote and TGBing; The Second Ascended...; And just maybe a security warning come alive...?)]

Oh right, that’s what I meant by it.

So in compensation,
There’s always a bigger fish - you can never be the biggest cell (base size) in your patch